Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study
| Autor: | Chiara Novielli, Ella Schaefer, Chiara Mandò, Irene Cetin, Stefania Di Francesco, Valeria Savasi, Silvia Maggini, Matteo Della Porta, Roberta Cazzola, Mauro Panteghini, Maddalena Massari |
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| Rok vydání: | 2020 |
| Předmět: |
Physiology
vitamin D law.invention Fetal Development 0302 clinical medicine Randomized controlled trial Pregnancy law Micronutrients 030212 general & internal medicine chemistry.chemical_classification 030219 obstetrics & reproductive medicine Nutrition and Dietetics neurodevelopment Prenatal Care docosahexaenoic acid Fetal Blood Micronutrient Treatment Outcome Docosahexaenoic acid Female Pregnancy Trimesters lcsh:Nutrition. Foods and food supply Adult maternal biomarkers Adolescent Docosahexaenoic Acids Nutritional Status lcsh:TX341-641 Article long-chain polyunsaturated fatty acids Young Adult 03 medical and health sciences medicine Vitamin D and neurology Humans Fetus business.industry Infant Newborn Fatty acid Maternal Nutritional Physiological Phenomena Metabolism medicine.disease chemistry supplementation Dietary Supplements business pregnant women Biomarkers Food Science |
| Zdroj: | Nutrients Volume 12 Issue 8 Nutrients, Vol 12, Iss 2432, p 2432 (2020) |
| ISSN: | 2072-6643 |
| Popis: | Maternal dietary intake during pregnancy needs to meet increased nutritional demands to maintain metabolism and to support fetal development. Docosahexaenoic acid (DHA) is essential for fetal neuro-/visual development and in immunomodulation, accumulating rapidly within the developing brain and central nervous system. Levels available to the fetus are governed by the maternal diet. In this multicenter, parallel, randomized controlled trial, we evaluated once-daily supplementation with multiple micronutrients and DHA (i.e., multiple micronutrient supplementation, MMS) on maternal biomarkers and infant anthropometric parameters during the second and third trimesters of pregnancy compared with no supplementation. Primary efficacy endpoint: change in maternal red blood cell (RBC) DHA (wt% total fatty acids) during the study. Secondary variables: other biomarkers of fatty acid and oxidative status, vitamin D, and infant anthropometric parameters at delivery. Supplementation significantly increased RBC DHA levels, the omega-3 index, and vitamin D levels. Subscapular skinfold thickness was significantly greater with MMS in infants. Safety outcomes were comparable between groups. This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting&mdash an important finding considering the essential roles of DHA and vitamin D. |
| Databáze: | OpenAIRE |
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