Colorectal carcinoma in Hong Kong: epidemiology and genetic mutations
| Autor: | Lap Ping Chung, Andrew H. Wyllie, Suet Yi Leung, S T Yuen, S. Y. Chan, I. S. C. Luk, J. C. I. Ho, Jwc Ho |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Time Factors Adolescent Colorectal cancer Disease Frameshift mutation Epidemiology Carcinoma Humans Medicine China Aged Aged 80 and over business.industry Incidence Incidence (epidemiology) Southern chinese Middle Aged Genes p53 medicine.disease Surgery Genes ras Oncology Mutation Hong Kong Female Colorectal Neoplasms business Research Article Demography |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1997.605 |
| Popis: | The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in Hong Kong with that of Scotland and other countries. Hong Kong showed a much higher incidence of colorectal carcinoma among the young age groups. By comparison with other countries, this raised incidence among the young appeared to be related to southern Chinese societies. The recent dramatic rise in colorectal cancer in Hong Kong was largely attributable to an increase in the over 50 years age group, while the young incidence remained unchanged. We also defined the mutation spectrum of p53 and Ki-ras in 67 unselected cases by direct DNA sequencing. Interestingly, insertion/deletion mutations in p53 from colorectal carcinoma in Hong Kong showed a significantly higher frequency (17.2%) than the Scottish data (0%) and the world database (6.6%), although the overall frequency of p53 mutation (43%) in Hong Kong was similar to others. The high incidence of colorectal carcinoma in young people and the raised proportion of frameshift mutations in p53 encourage further search for a genetic basis for susceptibility to this disease in the Hong Kong Chinese population. |
| Databáze: | OpenAIRE |
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