Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)

Autor:	Yasufumi Sawada, Kenji Otsubo, Noriko Koyabu, Tomohiro Honda, Hisakazu Ohtani, Yukihiko Dan, Ichiro Ieiri, Shun Higuchi
Rok vydání:	2004
Předmět:	Pharmacology Genetics chemistry.chemical_classification Pharmaceutical Science Heterozygote advantage Single-nucleotide polymorphism Amino acid substitution Biology Mdr1 gene Molecular biology Exon chemistry SNP Pharmacology (medical) Glycoprotein Gene
Zdroj:	Drug metabolism and pharmacokinetics. 17(5)
ISSN:	1347-4367
Popis:	Summary: We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug - resistance 1 ( MDR1 ) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P - glycoprotein ( MDR1 ); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5′-ATGAATCTGGAGG/AAAGACATGACCA-3′. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd857c3149e61cdbb08e233c4943cbe https://pubmed.ncbi.nlm.nih.gov/15618700 Zobrazit plný text záznamu Full Text from ScienceDirect