Rapid and sensitive method for determination of haloperidol in human samples using nitrogen—phosphorus selective detection
| Autor: | G. Bianchetti, P.L. Morselli |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Chromatography
Gas Time Factors Chromatography Nitrogen Chemistry medicine.medical_treatment Organic Chemistry Phosphorus General Medicine Plasma levels Pharmacology Biochemistry Nitrogen phosphorus Analytical Chemistry Azaperone medicine Haloperidol Humans In patient Routine analysis Antipsychotic Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Journal of Chromatography A. 153:203-209 |
| ISSN: | 0021-9673 |
| Popis: | A sensitive gas-chromatographic method for quantitative analysis of haloperidol in human plasma is described. The use of nitrogen—phosphorus selective detection reduces the time required for analysis. Azaperone is used as the internal reference standard. The method is suitable for the determination of haloperidol plasma levels in patients treated with doses ranging from 1.2 to 200 mg/day. No interference from drugs needed in the associated antipsychotic therapy has been found. The simplicity, specificity and sensitivity of the method make it suitable for routine analysis of haloperidol plasma levels in psychotic patients undergoing chronic treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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