Additional file 1: of GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice

Autor: Lenhart, Kaitlin, O’Neill, Thomas, Zhaokang Cheng, Dee, Rachel, Demonbreun, Alexis, Jianbin Li, Xiao, Xiao, McNally, Elizabeth, Mack, Christopher, Taylor, Joan
Rok vydání: 2015
Předmět:
DOI: 10.6084/m9.figshare.c.3606407_d1
Popis: Figure S1. TEM of GRAF1 tibialis anterior muscle. TEM (Ă 2500 magnification) reveals T-tubule abnormalities in muscle from GRAF1-deficient mice. Figure S2. Graf1-depleted mdx mice exhibit increased muscle growth. Comparison of body mass and gross muscle size reveals that young adult Graf1-depleted mdx mice exhibit increased muscle growth relative to littermate controls. Figure S3. GRAF1/dystrophin- depleted tibialis anterior muscles contain smaller but more numerous fibers. Comparison of 6-month-old muscle cross-sectional areas reveals that GRAF1/dystrophin-depleted tibialis anterior muscles contain smaller but more numerous fibers than littermate controls. Figure S4. Adult GRAF1/dystrophin- depleted diaphragms contain more numerous fibers and exhibit signs of reduced regenerative capacity. Comparison of 6-month-old diaphragm muscle cross-sectional areas reveals that GRAF1/dystrophin-depleted tissue contains more numerous fibers and has less regenerative potential than littermate controls.
Databáze: OpenAIRE
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