Ongoing pain in the MIA model of osteoarthritis
| Autor: | Frank Porreca, Alec Okun, Ping Liu, Jiyang Ren, Tamara King, Rui Chen Guo, Michael H. Ossipov, Jennifer Y. Xie |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Time Factors Pain Iodoacetates Osteoarthritis medicine.disease_cause Article Weight-bearing Rats Sprague-Dawley medicine Animals Referred pain business.industry General Neuroscience Chronic pain medicine.disease Rats Evoked pain Clonidine Disease Models Animal Allodynia Anesthesia Chronic Disease Hyperalgesia medicine.symptom business medicine.drug |
| Zdroj: | Neuroscience Letters. 493:72-75 |
| ISSN: | 0304-3940 |
| Popis: | Osteoarthritis (OA) is a chronic pain condition characterized by pain during joint use as well as pain at rest (i.e., ongoing pain). Although injection of monosodium iodoacetate (MIA) into the intra-articular space of the rodent knee is a well established model of OA pain that is characterized by changes in weight bearing and hypersensitivity to tactile and thermal stimuli, it is not known if this procedure elicits ongoing pain. Further, the time-course and possible underlying mechanisms of these components of pain remain poorly understood. In these studies, we demonstrated the presence of ongoing pain in addition to changes in weight bearing and evoked hypersensitivity. Twenty-eight days following MIA injection, spinal clonidine blocked changes in weight bearing and thermal hypersensitivity and produced place preference indicating that MIA induces ongoing and evoked pain. These findings demonstrate the presence of ongoing pain in this model that is present at a late-time point after MIA allowing for mechanistic investigation. |
| Databáze: | OpenAIRE |
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