Is Leber Hereditary Optic Neuropathy Treatable? Encouraging Results With Idebenone in Both Prospective and Retrospective Trials and An Illustrative Case
| Autor: | Khizer R. Khaderi, Alfredo A. Sadun, Esfandiar J. Sabet-Peyman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
LEBER HEREDITARY OPTIC NEUROPATHY medicine.medical_specialty Pediatrics Visual acuity genetic structures Ubiquinone Treatment outcome Optic Atrophy Hereditary Leber Antioxidants Ophthalmology medicine Humans Idebenone Prospective Studies Prospective cohort study Retrospective Studies Clinical Trials as Topic business.industry Retrospective cohort study Recovery of Function eye diseases Visual field Treatment Outcome Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Journal of Neuro-Ophthalmology. 32:54-57 |
| ISSN: | 1070-8022 |
| DOI: | 10.1097/wno.0b013e318241da45 |
| Popis: | A 31-year-old woman developed subacute bilateral visual loss over a 2-week period. Two months later, the diagnosis of Leber hereditary optic neuropathy (LHON) 11778/ND4 was established and the patient was treated with 900 mg of idebenone daily. Over the ensuing 9 months, visual acuity improved from 20/200 to 20/25 in each eye with near-total resolution in visual field abnormalities. Our case report is in agreement with 2 large published series of patients with LHON treated with idebenone, raising hope for treatment of this visually devastating mitochondrial disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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