Lanthanum Complex with Neridronic Acid: Synthesis and Properties
| Autor: | P. V. Dorovatovsky, A. V. Galantsev, Victor N. Khrustalev, D. V. Drobot |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: |
x-ray data
bisphosphonate Sodium chemistry.chemical_element Infrared spectroscopy 02 engineering and technology 010402 general chemistry 01 natural sciences lcsh:Chemistry Crystal Lanthanum QD1-999 chemistry.chemical_classification Hydrogen bond Nuclear magnetic resonance spectroscopy Polymer neridronic acid particle size 021001 nanoscience & nanotechnology 0104 chemical sciences Crystallography Chemistry lcsh:QD1-999 chemistry lanthanum neridronate Particle size 0210 nano-technology |
| Zdroj: | Тонкие химические технологии, Vol 14, Iss 2, Pp 70-77 (2019) |
| ISSN: | 2686-7575 2410-6593 |
| Popis: | Currently, various amino bisphosphonates are widely used in the treatment of many bone diseases. One of the most well-known complex compounds of neridronic acid (6-amino-1-hydroxyhexylidene-1,1- bisphosphonic acid) is sodium neridronate – a bisphosphonate, which is used to treat osteogenesis and Paget's disease. However, there is no data on compounds of neridronic acid with rare earth elements. A new complex of lanthanum with 6-amino-1-hydroxyhexylidene-1,1-bisphosphonic acid (I) was obtained and characterized by various physicochemical methods (chemical analysis, IR spectroscopy, solid-phase 31P NMR spectroscopy, optical microscopy, PCA, DTA). According to the research data the complex I has the composition {La[(H3N-(CH2)5-C(OH)(PO2(OH))2]2(H2O)2}[OH]·H2O and represents the coordination 1D-polymer due to two bridged phosphonic groups with lanthanum atoms in a tetragonal-antiprismatic environment. In a crystal, polymer chains form a 3D-frame porous structure by means of strong hydrogen bonds O─H ··· O and N─H ··· O with endless channels, available to include a variety of inorganic anions or small organic molecules. A study under the microscope showed that the sample is needle crystals (thin rods) of different lengths. The particle size distribution was obtained by laser diffraction, and the average particle size was determined: 50 µm in length and 2.5 µm in thickness. |
| Databáze: | OpenAIRE |
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