Prospective study of the correlation between admission plasma homocysteine levels and neurological outcome following subarachnoid hemorrhage: A case for the reverse epidemiology paradox?
| Autor: | Sivashanmugam Dhandapani, Sunil Gupta, Kanchan K Mukherjee, Mohammad Danish, Harnarayan Singh, Sachin Goudihalli, Anirudh Srinivasan, Manju Dhandapani, Suresh N. Mathuriya, Niranjan Khandelwal, Shanthanam Mahalingam |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Subarachnoid hemorrhage Multivariate analysis Homocysteine Glasgow Outcome Scale Logistic regression Gastroenterology chemistry.chemical_compound Risk Factors Internal medicine Epidemiology medicine Humans Prospective Studies Risk factor Prospective cohort study Aged business.industry Middle Aged Subarachnoid Hemorrhage Prognosis medicine.disease Surgery chemistry Multivariate Analysis Female Neurology (clinical) business |
| Zdroj: | Acta Neurochirurgica. 157:399-407 |
| ISSN: | 0942-0940 0001-6268 |
| DOI: | 10.1007/s00701-014-2297-0 |
| Popis: | Homocysteine (tHcy) has been known over the last few decades for its putative impact on vascular diseases, but has not been evaluated much in patients with subarachnoid hemorrhage (SAH). This study was carried out to assess its prognostic impact on the neurological outcome following SAH. Admission plasma tHcy was evaluated in 90 SAH patients and prospectively studied in relation to various factors and the Glasgow Outcome Scale (GOS) at 3 months. Univariate and multivariate analyses were performed using SPSS 21. tHcy was significantly higher following SAH compared to matched controls [median (IQR): 25.7 (17.3–35.9) vs. 14.0 (9.8–17.6) μmol/l, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink