Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis
| Autor: | Priyank V. Kumar, Chong You Chen, Zih Yu Yu, Jia Wei Yang, Sheng Jen Cheng, Shiue Luen Chen, Kuan Yu Hsieh, Jason Chia-Hsun Hsieh, Shien Fong Lin, Guan-Yu Chen |
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| Rok vydání: | 2019 |
| Předmět: |
General Chemical Engineering
Review 02 engineering and technology circulating tumor cells Exosome law.invention Nanomaterials 03 medical and health sciences Circulating tumor cell law medicine exosome General Materials Science Liquid biopsy 030304 developmental biology circulating tumor DNA 0303 health sciences liquid biopsy Graphene Chemistry Cancer 021001 nanoscience & nanotechnology medicine.disease Microvesicles graphene oxide 0210 nano-technology Biosensor Biomedical engineering |
| Zdroj: | Nanomaterials |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano9121725 |
| Popis: | Liquid biopsies use blood or urine as test samples, which are able to be continuously collected in a non-invasive manner. The analysis of cancer-related biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA, and exosomes provides important information in early cancer diagnosis, tumor metastasis detection, and postoperative recurrence monitoring assist with clinical diagnosis. However, low concentrations of some tumor markers, such as CTCs, ctDNA, and microRNA, in the blood limit its applications in clinical detection and analysis. Nanomaterials based on graphene oxide have good physicochemical properties and are now widely used in biomedical detection technologies. These materials have properties including good hydrophilicity, mechanical flexibility, electrical conductivity, biocompatibility, and optical performance. Moreover, utilizing graphene oxide as a biosensor interface has effectively improved the sensitivity and specificity of biosensors for cancer detection. In this review, we discuss various cancer detection technologies regarding graphene oxide and discuss the prospects and challenges of this technology. |
| Databáze: | OpenAIRE |
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