[Regulation of pyruvate transport in mitochondria by thyroid hormones]
| Autor: | Turakulov IaKh, Mirmakhmudova Si, Gaĭnutdinov MKh |
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| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Insulin Pyruvate transport Thyroidectomy General Medicine Mitochondrion General Biochemistry Genetics and Molecular Biology Diaphragm (structural system) chemistry.chemical_compound Endocrinology chemistry Cytoplasm Thyroid hormones Internal medicine medicine Ammonium |
| Zdroj: | Yalkin Turakulov Europe PubMed Central |
| Popis: | During thyroidectomy, the stimulating action of the catalytic amounts of a thermostable fraction of rat liver and diaphragm cytoplasm on Ca2+ transport in mitochondria, which indicates the decrease of the activity of an insulin-dependent cytoplasmic regulator (IDR) in insulin target organs. Thyroidectomized rats also manifested a decrease in blood insulin and glucose concentrations. Administration of the physiological doses of thyroxine produced an increase in both blood glucose concentration and IDR activity in the liver and diaphragm of thyroidectomized rats. Experiments with measuring the kinetics of the swelling of deenergized mitochondria in isoosmotic solution of ammonium pyruvate demonstrated the inhibition of liver mitochondrial swelling in thyroidectomized rats. |
| Databáze: | OpenAIRE |
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