| Popis: |
The effects of methylguanidine (MG) were studied in proximal and distal tubules of the cortical nephrons of the rat kidney by the aid of various micropuncture techniques. Methylguanidine (5 × 10-4M/kg intravenously, as a bolus) depressed fluid and sodium reabsorption without affecting GFR. In proximal convoluted tubules, intravenous MG did not significantly affect the rate of isotonic fluid reabsorption measured with the split oil droplet technique; whereas, when MG (1 mM/1) was applied both from the peritubular side and intratubularly, isotonic fluid reabsorption was slightly depressed (p < 0.05). In the distal tubule, intravenous MG depressed fluid and sodium reabsorption. |
