Supplementary Data: Figure S1-3 and Table S1-S5 from Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody–Drug Conjugate in Patient-derived Xenografts

Autor: O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Rok vydání: 2023
Popis: Supplemental Figure 1: heavy and light chain sequences for 5F9, the human IgG1 monoclonal antibody (mAb) targeting the extracellular domain of GCC as described previously Supplemental Figure 2: Characterization of TAK-164 and chKTI-DGN549 by A) SDS PAGE gel and B) by Liquid chromatography-mass spectrometry (LC-MS) Supplemental Figure 3: In vivo activity of TAK-164 in PHTXM-46C Supplemental Table 1: Growth rate inhibition following treatment with TAK-164 and B) chKTI-ADC in PHTX and cell derived xenograft models Supplemental Table 2: Growth Rate Inhibition and associated statistics for HEK293 GCC#2 Supplemental Table 3: Growth Rate Inhibition and associated statistics for PHTX-09C Supplemental Table 4: Growth Rate Inhibition and associated statistics for PHTX-17C Supplemental Table 5: Growth Rate Inhibition and associated statistics for PHTX-11C
Databáze: OpenAIRE