Ran, a GTPase involved in nuclear processes: its regulators and effectors
| Autor: | Johanna M. Avis, Paul Clarke |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Cell Nucleus
Genetics Leucine Zippers GTP' Effector Cell Cycle Nuclear Proteins Cell Biology GTPase Importin Cell cycle Biology GTP Phosphohydrolases Cell biology DNA-Binding Proteins Nuclear Pore Complex Proteins ran GTP-Binding Protein GTP-Binding Proteins Ran Animals Humans Small GTPase Nuclear protein Molecular Chaperones |
| Zdroj: | Journal of Cell Science. 109:2423-2427 |
| ISSN: | 1477-9137 0021-9533 |
| DOI: | 10.1242/jcs.109.10.2423 |
| Popis: | Ran is a small GTPase that has been implicated in a variety of nuclear processes, including the maintainance of nuclear structure, protein import, mRNA processing and export, and cell cycle regulation. There has been significant progress in determining the role of Ran in nuclear protein import. However, it has been unclear whether this role is sufficient to account for the diverse effects of disrupting Ran functions. Recently, several proteins have been identified that bind specifically to Ran and are, therefore, possible effectors. Other experiments using dominant mutants of Ran that block its GTP/GDP cycle have suggested that Ran may have multiple roles. Here, these results are summarised and discussed with respect to the action of Ran. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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