p53 and Cell Fate: Sensitizing Head and Neck Cancer Stem Cells to Chemotherapy
| Autor: | Christie Rodriguez-Ramirez, Jacques E. Nör |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Antineoplastic Agents Cell fate determination Self renewal Article 03 medical and health sciences Cancer stem cell Antineoplastic Combined Chemotherapy Protocols medicine Animals Humans Cell Self Renewal Head and neck Chemotherapy Genome business.industry Head and neck cancer Cell Differentiation medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Drug Resistance Neoplasm Head and Neck Neoplasms Neoplastic Stem Cells Cancer research Disease Susceptibility Tumor Suppressor Protein p53 Stem cell business Reprogramming Signal Transduction |
| Zdroj: | Critical Reviews™ in Oncogenesis. 23:173-187 |
| ISSN: | 0893-9675 |
| DOI: | 10.1615/critrevoncog.2018027353 |
| Popis: | Head and neck cancers are deadly diseases that are diagnosed annually in approximately half a million individuals worldwide. Growing evidence supporting a role for cancer stem cells (CSCs) in the pathobiology of head and neck cancers has led to increasing interest in identifying therapeutics to target these cells. Apart from the canonical tumor-suppressor functions of p53, emerging research supports a significant role for this protein in physiological stem cell and CSC maintenance and reprogramming. Therefore, p53 has become a promising target to sensitize head and neck CSCs to chemotherapy. In this review, we highlight the role of p53 in stem cell maintenance and discuss potential implications of targeting p53 to treat patients with head and neck cancers. |
| Databáze: | OpenAIRE |
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