Induction of the unfolded protein response (UPR) during Marek's disease virus (MDV) infection
Autor: | Mark S. Parcells, Sabari Nath Neerukonda, Upendra K. Katneni, Serguei P. Golovan, Matthew Bott |
---|---|
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
animal structures XBP1 animal diseases viruses Biology Virus 03 medical and health sciences Immune system immune system diseases hemic and lymphatic diseases Virology Marek Disease Animals Herpesvirus 3 Gallid Lymphocytes Cells Cultured Poultry Diseases ATF6 Gene Expression Profiling Endoplasmic reticulum 030104 developmental biology Cell culture Tumor progression Host-Pathogen Interactions Unfolded Protein Response Unfolded protein response Chickens |
Zdroj: | Virology. 522:1-12 |
ISSN: | 0042-6822 |
DOI: | 10.1016/j.virol.2018.06.016 |
Popis: | Marek's disease (MD) is a pathology of chickens associated with paralysis, immune suppression, and the rapid formation of T-cell lymphomas. MD is caused by the herpesvirus, Marek's disease virus (MDV). We examined endoplasmic reticulum (ER) stress and the activation of unfolded protein response (UPR) pathways during MDV infection of cells in culture and lymphocytes in vivo. MDV strains activate the UPR as measured by increased mRNA expression of GRP78/BiP with concomitant XBP1 splicing and induction of its target gene, EDEM1. Cell culture replication of virulent, but not vaccine MDVs, activated the UPR at late in infection. Pathotype-associated UPR activation was induced to a greater level by a vv + MDV. Discrete UPR activation was observed during MDV in vivo infection, with the level of UPR modulation being affected by the MDV oncoprotein Meq. Finally, ATF6 was found to be activated in vv + MDV-induced primary lymphomas, suggesting a possible role in tumor progression. |
Databáze: | OpenAIRE |
Externí odkaz: |
Pro tento záznam nejsou dostupné žádné jednotky.