Phosphate binding by sucroferric oxyhydroxide ameliorates renal injury in the remnant kidney model
Autor: | Yutaka Miura, Kazuhiro Sakai, Kenichi Ishizawa, Hiroki Omizo, Hiroshi Kawachi, Takanori Kumagai, Shigeru Shibata, Yoshikazu Nemoto, Takeshi Shiraishi, Chikayuki Morimoto, Yoshihide Fujigaki, Osamu Yamazaki, Makoto Kuro-o, Yoshifuru Tamura, Shunya Uchida |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Sucrose medicine.medical_treatment Biopsy lcsh:Medicine Ferric Compounds Article Phosphates 03 medical and health sciences Ectopic calcification chemistry.chemical_compound 0302 clinical medicine Fibrosis Internal medicine medicine Animals Renal Insufficiency Chronic lcsh:Science Kidney Multidisciplinary Glomerulosclerosis Focal Segmental Podocytes lcsh:R Glomerulosclerosis medicine.disease Phosphate Immunohistochemistry Nephrectomy Rats Disease Models Animal Drug Combinations 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Albuminuria lcsh:Q Disease Susceptibility medicine.symptom 030217 neurology & neurosurgery Biomarkers Kidney disease |
Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
ISSN: | 2045-2322 |
Popis: | Recent clinical studies indicate that the disturbed phosphate metabolism in chronic kidney disease (CKD) may facilitate kidney injury; nonetheless, the causal role of phosphate in CKD progression remains to be elucidated. Here, we show that intestinal phosphate binding by sucroferric oxyhydroxide (SF) ameliorates renal injury in the rat remnant kidney model. Sprague-Dawley rats received 5/6 nephrectomy (RK) and had a normal chow or the same diet containing SF (RK + SF). RK rats showed increased plasma FGF23 and phosphate levels, which were suppressed by SF administration. Of note, albuminuria in RK rats was significantly ameliorated by SF at both 4 and 8 weeks. SF also attenuated glomerulosclerosis and tubulointerstitial injury. Moreover, several different approaches confirmed the protective effects on podocytes, explaining the attenuation of glomerulosclerosis and albuminuria observed in this study. As a possible mechanism, we found that SF attenuated renal inflammation and fibrosis in RK rats. Interestingly, von Kossa staining of the kidney revealed calcium phosphate deposition in neither RK nor RK + SF rats; however, plasma levels of calciprotein particles were significantly reduced by SF. These data indicate that latent positive phosphate balance accelerates CKD progression from early stages, even when overt ectopic calcification is absent. |
Databáze: | OpenAIRE |
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