Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder
| Autor: | Masaki Kato, Megumi Yamashita, Toshihiko Kinoshita, Masataka Wakeno, Alessandro Serretti, Syunsuke Watanabe, Yuka Hosoi, Yoshiteru Takekita, Gaku Okugawa, Junichi Azuma, Tsuyoshi Fukuda |
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| Přispěvatelé: | Kato M., Fukuda T., Wakeno M., Okugawa G., Takekita Y., Watanabe S., Yamashita M., Hosoi Y., Azuma J., Kinoshita T., Serretti A. |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
medicine.medical_specialty Linkage disequilibrium Single-nucleotide polymorphism Biology Pharmacology Polymorphism Single Nucleotide Linkage Disequilibrium SEROTONIN 1A RECEPTOR Cellular and Molecular Neuroscience Internal medicine Genotype medicine Humans SNP TREATMENT RESPONSE Genetics (clinical) rs6295 DNA Primers Depressive Disorder Major Base Sequence PHARMACOGENETICS DEPRESSION medicine.disease Minor allele frequency Psychiatry and Mental health Receptor Serotonin 5-HT1A Antidepressive Agents Second-Generation Major depressive disorder Selective Serotonin Reuptake Inhibitors Pharmacogenetics |
| Zdroj: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :115-123 |
| ISSN: | 1552-485X 1552-4841 |
| DOI: | 10.1002/ajmg.b.30783 |
| Popis: | Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Rs6295C/G SNP in the 5-HT1A gene (HTR1A) has been found to affect the expression and function of HTR1A. In fact rs6295C/G is in strong linkage disequilibrium with other polymorphisms of HTR1A suggesting that those functional effects could be associated with polymorphisms other than or together with the synonymous rs6295C/G. In the present study we examined the possible association of a panel of markers in strong linkage disequilibrium of the HTR1A with SSRI/SNRI response in 137 Japanese major depression subjects followed for 6 weeks. We observed a significant association of better response to antidepressant in rs10042486C/C (P |
| Databáze: | OpenAIRE |
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