Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice
| Autor: | Eman Selima, Omar Hamed, Amany Hussein Kazem, Magda Nasr |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Carcinoma Hepatocellular Curcumin Angiogenesis Angiotensin-Converting Enzyme Inhibitors Antineoplastic Agents Pharmacology Neovascularization chemistry.chemical_compound Mice Perindopril medicine Animals Diethylnitrosamine Leflunomide biology Neovascularization Pathologic business.industry Liver Neoplasms Angiotensin-converting enzyme Isoxazoles medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit digestive system diseases Vascular endothelial growth factor Platelet Endothelial Cell Adhesion Molecule-1 chemistry Liver Hepatocellular carcinoma Antirheumatic Agents biology.protein Carcinogens Drug Therapy Combination medicine.symptom business medicine.drug |
| Zdroj: | European journal of pharmacology. 723 |
| ISSN: | 1879-0712 |
| Popis: | No effective chemopreventive agent has been approved against hepatocellular carcinoma (HCC) to date. Since HCC is one of the hypervascular solid tumors, blocking angiogenesis represents an intriguing approach to HCC chemoprevention. The aim of the current study was to examine the combined effect of the anti-angiogenic agents: leflunomide; a disease modifying antirheumatic drug, perindopril; an angiotensin converting enzyme inhibitor (ACEI) and curcumin; the active principle of turmeric, on diethylnitrosamine (DEN)-induced HCC in mice. Eight weeks following DEN administration, there was a significant rise in immunohistochemical staining of CD31-positive endothelial cells and consequently hepatic microvessel density (MVD) as compared to normal liver. DEN treatment was associated with elevation in hepatic vascular endothelial growth factor (VEGF) level as compared to normal controls (P |
| Databáze: | OpenAIRE |
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