Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors

Autor:	Eun Kyung Lee, Pravin Iyer, Sandra Steiner, Matthew C. Lucas, Ryan Craig Schoenfeld, Hai-Ying Cai, David S. Carter, Robert James Weikert, Marzia Villa
Rok vydání:	2009
Předmět:	Stereochemistry Clinical Biochemistry hERG Pharmaceutical Science Biochemistry Cytochrome P-450 CYP2D6 Inhibitors chemistry.chemical_compound Heterocyclic Compounds Drug Discovery Cytochrome P-450 CYP3A Humans Neurotransmitter Uptake Inhibitors Neurotransmitter Molecular Biology Cytochrome P-450 CYP3A Inhibitors biology Chemistry Organic Chemistry Drug interaction Monoamine neurotransmitter Cytochrome P-450 CYP2D6 Microsomes Liver biology.protein Molecular Medicine Monoamine reuptake inhibitor Reuptake inhibitor
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:4630-4633
ISSN:	0960-894X
Popis:	A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbbdaed6bc94e709f0bbe772f9fd531 https://doi.org/10.1016/j.bmcl.2009.06.076 Zobrazit plný text záznamu Full Text from ScienceDirect