Post-myocardial Infarct Inflammation and the Potential Role of Cell Therapy
| Autor: | Vanessa-leigh van Zuylen, Willem E. Fibbe, Helene Roelofs, Martin J. Schalij, Melina C. den Haan, Sacha B. Geutskens, Douwe E. Atsma |
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| Rok vydání: | 2015 |
| Předmět: |
Cell- and Tissue-Based Therapy
Inflammation Bioinformatics Cell therapy medicine Animals Humans Pharmacology (medical) Myocardial infarction Pharmacology Mesenchymal stromal cell business.industry Mesenchymal stem cell Inflammatory response General Medicine medicine.disease Reperfusion Injury Heart failure Immunology medicine.symptom Stem cell Cardiology and Cardiovascular Medicine business Reperfusion injury Adult stem cell |
| Zdroj: | Cardiovascular Drugs and Therapy, 29(1), 59-73 |
| ISSN: | 1573-7241 0920-3206 |
| Popis: | Myocardial infarction triggers reparative inflammatory processes programmed to repair damaged tissue. However, often additional injury to the myocardium occurs through the course of this inflammatory process, which ultimately can lead to heart failure. The potential beneficial effects of cell therapy in treating cardiac ischemic disease, the number one cause of death worldwide, are being studied extensively, both in clinical trials using adult stem cells as well as in fundamental research on cardiac stem cells and regenerative biology. This review summarizes the current knowledge on molecular and cellular processes implicated in post-infarction inflammation and discusses the potential beneficial role cell therapy might play in this process. Due to its immunomodulatory properties, the mesenchymal stromal cell is a candidate to reverse the disease progression of the infarcted heart towards heart failure, and therefore is emphasized in this review. |
| Databáze: | OpenAIRE |
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