Effect of indomethacin on the renal response to angiotensin II receptor blockade in healthy subjects
| Autor: | Jürg Nussberger, Hans R. Brunner, Susanne Meilenbrock, Anne F. Fricker, Michel Burnier |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Angiotensin receptor NSAIDs Indomethacin Natriuresis Tetrazoles Angiotensin II receptor antagonist Angiotensin-Converting Enzyme Inhibitors Pharmacology urologic and male genital diseases hemodynamics Kidney Renal Circulation prostaglandins Angiotensin Receptor Antagonists Enalapril Reference Values Internal medicine medicine Humans Single-Blind Method Cross-Over Studies biology business.industry renal function Anti-Inflammatory Agents Non-Steroidal Angiotensin-converting enzyme Valine ACE inhibition Angiotensin II Endocrinology Valsartan Nephrology ACE inhibitor biology.protein business medicine.drug |
| Zdroj: | Kidney international. 54(6) |
| ISSN: | 0085-2538 |
| Popis: | Effect of indomethacin on the renal response to angiotensin II receptor blockade in healthy subjects. Background Non-steroidal anti-inflammatory drugs are known to promote sodium retention and to blunt the blood pressure lowering effects of several classes of antihypertensive agents including beta-blockers, diuretics and angiotensin converting enzyme (ACE) inhibitors. The purpose of the present study was to investigate the acute and sustained effects of indomethacin on the renal response to the angiotensin II receptor antagonist valsartan and to the ACE inhibitor enalapril. Methods Twenty normotensive subjects maintained on fixed sodium intake (100mmol sodium/day) were randomized to receive for one week: valsartan 80mg o.d., enalapril 20mg o.d., valsartan 80mg o.d. + indomethacin 50mg bid and enalapril 20mg o.d. + indomethacin 50mg bid. This single-blind study was designed as a parallel (valsartan vs. enalapril) and cross-over trial (valsartan or enalapril vs. valsartan + indomethacin or enalapril + indomethacin). Renal hemodynamics and urinary electrolyte excretion were measured for six hours after the first and seventh administration of each treatment regimen. Results The results show that valsartan and enalapril have comparable renal effects characterized by no change in glomerular filtration rate and significant increases in renal plasma flow and sodium excretion. The valsartan- and enalapril-induced renal vasodilation is not significantly blunted by indomethacin. However, indomethacin similarly abolishes the natriuresis induced by the angiotensin II antagonist and the ACE inhibitor. Conclusions This observation suggests that although angiotensin receptor antagonists do not affect prostaglandin metabolism, the administration of a non-steroidal anti-inflammatory drug blunts the natriuretic response to angiotensin receptor blockade. |
| Databáze: | OpenAIRE |
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