Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury
| Autor: | Qingqing Wang, Mengke Ye, Fangzhou Qi, Jiaying Zhou, Yining Wang, Chongan Huang, Xiang-Yang Wang, Feifan Chu, Hao Qian, Zhi Lin, Weiqi Zhang, ChenLin Dong, Haiming Jin |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cord QH301-705.5 Central nervous system Caspase 3 Pharmacology Neuroprotection 03 medical and health sciences Cell and Developmental Biology 0302 clinical medicine medicine Biology (General) Spinal cord injury Original Research business.industry Endoplasmic reticulum Cell Biology Nerve injury medicine.disease Spinal cord central nervous system spinal cord injury patchouli alcohol 030104 developmental biology medicine.anatomical_structure blood-spinal cord barrier endoplasmic reticulum stress medicine.symptom business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| ISSN: | 2296-634X |
| Popis: | Spinal cord injury (SCI) is a destructive and complex disorder of the central nervous system (CNS) for which there is no clinical treatment. Blood-spinal cord barrier (BSCB) rupture is a critical event in SCI that aggravates nerve injury. Therefore, maintaining the integrity of the BSCB may be a potential method to treat SCI. Here, we showed that patchouli alcohol (PA) exerts protective effects against SCI. We discovered that PA significantly prevented hyperpermeability of the BSCB by reducing the loss of tight junctions (TJs) and endothelial cells. PA also suppressed endoplasmic reticulum stress and apoptosis in vitro. Furthermore, in a rat model of SCI, PA effectively improved neurological deficits. Overall, these results prove that PA exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for SCI treatment. |
| Databáze: | OpenAIRE |
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