The Differentiation-Associated Linker Histone, H1.0, during the in Vitro Aging and Senescence of Human Diploid Fibroblasts
| Autor: | Kalliope E. Sekeri-Pataryas, Thomae G. Sourlingas |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Senescence
Aging Heterochromatin Cellular differentiation Mitosis In Vitro Techniques Biology General Biochemistry Genetics and Molecular Biology Chromatin remodeling Histones History and Philosophy of Science Histone H1 Animals Humans RNA Messenger Phosphorylation Alleles Cellular Senescence Genetics General Neuroscience Cell Differentiation Fibroblasts Diploidy Chromatin Cell biology Histone biology.protein Cell aging |
| Zdroj: | Annals of the New York Academy of Sciences. 1100:361-367 |
| ISSN: | 0077-8923 |
| Popis: | There are numerous similarities between aging/senescence and differentiation. One key similarity is that in both biological processes chromatin remodeling events occur. It is now known that during both processes there is a reorganization of eu- and heterochromatic domains and an increase in heterochromatin, known as heterochromatinization. Previous work of more than two decades has shown that the replacement H1 linker histone subtype, H1.0, accumulates during terminal differentiation in numerous cell/tissue systems. However, work with this differentiation-associated H1 subtype in aging cell systems has only recently been accomplished. In this article, we outline the cumulative results from our investigations of H1.0 protein and mRNA levels in the in vitro aging cell system of human diploid fibroblasts (HDFs) and discuss the potential rationale of why this particular subtype was found to accumulate during both these processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |