Effects of Perturbation Velocity, Direction, Background Muscle Activation, and Task Instruction on Long-Latency Responses Measured From Forearm Muscles
| Autor: | Paria Arfa Fatollahkhani, Andrea Zonnino, Jacob Weinman, Rebecca C. Nikonowicz, Fabrizio Sergi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
stretch reflex
electromyography Perturbation (astronomy) motor neurophysiology Neurosciences. Biological psychiatry. Neuropsychiatry Electromyography Wrist Behavioral Neuroscience Nuclear magnetic resonance Forearm medicine Extensor Carpi Ulnaris Torque Stretch reflex Biological Psychiatry Original Research Physics robotics medicine.diagnostic_test long latency responses Muscle activation Long latency Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology RC321-571 Biomedical engineering Neuroscience |
| Zdroj: | Frontiers in Human Neuroscience Frontiers in Human Neuroscience, Vol 15 (2021) |
| ISSN: | 1662-5161 |
| Popis: | The centeral nervous system uses feedback processes that occur at multiple time scales to control interactions with the environment. Insight on the neuromechanical mechanisms subserving the faster feedback processes can be gained by applying rapid mechanical perturbations to the limb, and observing the ensuing muscle responses using electromyography (EMG). The long-latency response (LLR) is the fastest process that directly involve cortical areas, with a motorneuron response measurable 50 ms following an imposed limb displacement. Several behavioral factors concerning perturbation mechanics and the active role of muscles prior or during the perturbation can modulate the long-latency response amplitude (LLRa) in the upper limbs, but the interaction between many of these factors had not been systematically studied before.We conducted a behavioral study on thirteen healthy individuals to determine the effect and interaction of four behavioral factors -- background muscle torque, perturbation direction, perturbation velocity, and task instruction -- on the LLRa evoked from the flexor carpi radialis (FCR) and extensor carpi ulnaris (ECU) muscles following the application of wrist displacements. The effects of the four factors listed above were quantified using both a 0D statistical analysis on the average perturbation-evoked EMG signal in the period corresponding to an LLR, and using a timeseries analysis of EMG signals.All factors significantly modulated LLRa, and that their combination nonlinearly contributed to modulating the LLRa. Specifically, all the three-way interaction terms that could be computed without including the interaction between instruction and velocity significantly modulated the LLR. Analysis of the three-way interaction terms of the 0D model indicated that for the ECU muscle, the LLRa evoked when subjects are asked to maintain their muscle activation in response to the perturbations (DNI) was greater than the one observed when subjects yielded (Y) to the perturbations (ΔLLRa — DNI vs. Y: 1.76±0.16 nu, p |
| Databáze: | OpenAIRE |
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