Number needed to treat for interleukin inhibitors approved for the treatment of moderate-to-severe plaque psoriasis in Italy
| Autor: | Alessia Maiorino, Antonio Costanzo, Silvia Antonelli, Serena Losi, Roberto Ravasio |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Number needed to treat
medicine.medical_specialty Risankizumab business.industry Ixekizumab Health Policy Brodalumab Tildrakizumab Interleukin inhibitor 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis Area and Severity Index Internal medicine Ustekinumab Medical technology medicine Secukinumab Plaque psoriasis 030212 general & internal medicine R855-855.5 business medicine.drug |
| Zdroj: | Global & Regional Health Technology Assessment, Vol 8 (2021) |
| ISSN: | 2283-5733 2284-2403 |
| DOI: | 10.33393/grhta.2021.2222 |
| Popis: | Background: Interleukin (IL) inhibitors achieve greater levels of efficacy than older systemic therapies. We calculated the number needed to treat (NNT) of ixekizumab compared with other IL inhibitors approved in Italy for the treatment of moderate-to-severe plaque psoriasis. Methods: The clinical efficacy was evaluated in terms of NNT, based on the results of a recent network meta-analysis (NMA) by the Cochrane Database of Systematic Reviews. The NMA investigated many systemic and biological treatments, but this analysis compared only the efficacy of the following IL inhibitors – brodalumab, guselkumab, ixekizumab, risankizumab, secukinumab, tildrakizumab and ustekinumab – for patients with moderate-to-severe plaque psoriasis. Drugs were compared and ranked according to effectiveness considering the PASI (Psoriasis Area and Severity Index) 90 score. Results: One-hundred and forty trials (51,749 patients) were included in the NMA. Considering the proportion of patients who achieve PASI90, ixekizumab showed the lowest NNT among all comparators (ixekizumab 2.01 [2.46-3.00]; risankizumab 2.05 [2.50-3-05]; guselkumab 2.16 [2.68-3.36]; secukinumab 2.40 [2.90-3.51]; brodalumab 2.61 [3.18-3.88]; ustekinumab 3.44 [4.12-4.95]; tildrakizumab 3.10 [4.15-5.59]. Conclusion: The findings show that ixekizumab is the most effective option (NNT) for the treatment of moderate-to-severe plaque psoriasis. |
| Databáze: | OpenAIRE |
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