Longitudinal Evaluation of Bone Mineral Density and Bone Metabolism Markers in Patients with Indolent Systemic Mastocytosis Without Osteoporosis
Autor: | Gaia Tripi, I. Gavioli, Luca Idolazzi, Cristian Caimmi, Davide Gatti, Anna Artuso, Massimiliano Bonifacio, Ombretta Viapiana, Maurizio Rossini, Roberta Zanotti |
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Rok vydání: | 2016 |
Předmět: |
musculoskeletal diseases
0301 basic medicine Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis Population Bone Indolent systemic mastocytosis Vitamin D 030209 endocrinology & metabolism Gastroenterology Bone and Bones Bone remodeling 03 medical and health sciences Basal (phylogenetics) chemistry.chemical_compound 0302 clinical medicine Endocrinology Mastocytosis Systemic Bone Density Internal medicine medicine Vitamin D and neurology Humans Orthopedics and Sports Medicine Longitudinal Studies Systemic mastocytosis education Aged Bone mineral education.field_of_study business.industry Middle Aged medicine.disease 030104 developmental biology chemistry Calcium Female Cholecalciferol business Biomarkers |
Zdroj: | Calcified tissue international. 100(1) |
ISSN: | 1432-0827 |
Popis: | Systemic Mastocytosis has been long identified as a potential cause of osteoporosis; nevertheless, data regarding longitudinal variation of bone mineral density (BMD) in patients with indolent systemic mastocytosis (ISM) are missing . We studied BMD variation at lumbar spine and proximal hip after 30-month (±6 months) follow-up in a large cohort of patients (83) with ISM without osteoporosis, supplementated with vitamin D and/or calcium when needed. We also analyzed the correlation between variation of BMD, basal serum tryptase levels and bone turnover markers (BTM). Sixty-four percent of our population was male; mean age was 52.1 (±11.5) years. Vitamin D insufficiency (serum levels of 25-OH-vitamin D, 25OHD, lower than 75 nmol/L) was found in more than 70 % of patients. After a follow-up of 30 ± 6 months with only vitamin D (5000–7500 IU weekly of oral cholecalciferol) or calcium (500 mg/die) supplementation when needed, we observed 2.1 % increase in BMD at lumbar spine, with no significant changes at hip. At the end of follow-up, almost 60 % of patients showed 25OHD serum levels still lower than recommended, despite vitamin D supplementation. Reduction in BMD after follow-up significantly correlated with high C-telopeptide of type I collagen serum levels at the time of diagnosis. In patients with ISM without osteoporosis, a routinary BMD evaluation within a time |
Databáze: | OpenAIRE |
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