Bet v 1 triggers antiviral-type immune signalling in birch-pollen-allergic individuals
| Autor: | Lukas Wisgrill, Nanna Fyhrquist, Joseph Ndika, Laura Paalanen, Angelika Berger, Tiina Laatikainen, Piia Karisola, Tari Haahtela, Harri Alenius |
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| Přispěvatelé: | HUMI - Human Microbiome Research, Medicum, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
EXPRESSION
Adolescent Immunology immune network systems immunology Antiviral Agents DENDRITIC CELLS DISPARITIES Bet v 1 Hypersensitivity Immunology and Allergy Humans TRANSCRIPTOME DNA METHYLATION Betula Plant Proteins T-CELL RESPONSES CHILDHOOD ASTHMA Allergens Antigens Plant Immunoglobulin E MICROBIOTA macrophages SENSITIZATION GENOME 3121 General medicine internal medicine and other clinical medicine Leukocytes Mononuclear Pollen birch allergy |
| Popis: | Background In allergic patients, clinical symptoms caused by pollen remind of symptoms triggered by viral respiratory infections, which are also the main cause of asthmatic exacerbations. In patients sensitized to birch pollen, Bet v 1 is the major symptom-causing allergen. Immune mechanisms driving Bet v 1-related responses of human blood cells have not been fully characterized. Objective To characterize the immune response to Bet v 1 in peripheral blood in patients allergic to birch pollen. Methods The peripheral blood mononuclear cells of birch-allergic (n = 24) and non-allergic (n = 47) adolescents were stimulated ex-vivo followed by transcriptomic profiling. Systems-biology approaches were employed to decipher disease-relevant gene networks and deconvolution of associated cell populations. Results Solely in birch-allergic patients, co-expression analysis revealed activation of networks of innate immunity and antiviral signalling as the immediate response to Bet v 1 stimulation. Toll-like receptors and signal transducer transcription were the main drivers of gene expression patterns. Macrophages and dendritic cells were the main cell subsets responding to Bet v 1. Conclusions and clinical relevance In birch-pollen-allergic patients, the activated innate immune networks seem to be, in part, the same as those activated during viral infections. This tendency of the immune system to read pollens as viruses may provide new insight to allergy prevention and treatment. |
| Databáze: | OpenAIRE |
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