MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
| Autor: | Hanaa M. Abdeen, Mohamed A. El-Hadidy, Mohammad Al-Harrass, Sherin M. Abd El-Aziz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Article Subject lcsh:Medicine Polymorphism Single Nucleotide Gastroenterology behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology Gene Frequency Internal medicine Genotype mental disorders medicine Humans Mthfr c677t Genetic Predisposition to Disease Bipolar disorder Age of Onset Allele Allele frequency Genetic Association Studies Methylenetetrahydrofolate Reductase (NADPH2) Genetics General Immunology and Microbiology biology business.industry lcsh:R General Medicine medicine.disease digestive system diseases Methylenetetrahydrofolate reductase Schizophrenia biology.protein Egypt Female Restriction fragment length polymorphism Age of onset business Research Article |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2014/318483 |
| Popis: | Objective. Several studies with contradictory results from different cultures about association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in schizophrenia and bipolar disorders. Little is known about this association in Arab culture and Egypt. So the present study aimed to assess the association of MTHFR C677T polymorphism in bipolar disorder (BD) and schizophrenia in comparison to control group. The association between MTHFR C677T polymorphism and the age at onset in schizophrenia or BD was also studied.Methods. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to examine the genotype and allele frequencies of MTHFR C677T polymorphism in 149 healthy subjects and 134 bipolar and 103 schizophrenia patients.Results. In BD and schizophrenia, there was a higher prevalence of MTHFR C677T polymorphism than healthy subjects. Earlier age at onset was found in patients with BD, carrying one copy of the T allele or CT genotypes but not in patients with schizophrenia.Conclusion. The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia. |
| Databáze: | OpenAIRE |
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