Neural Correlates of Stress-Induced and Cue-Induced Drug Craving: Influences of Sex and Cocaine Dependence
| Autor: | Cheryl Lacadie, Keri Tuit, Marc N. Potenza, Robert K. Fulbright, Kwangik Hong, Rajita Sinha |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Relaxation medicine.medical_specialty Poison control Anxiety Cocaine dependence Cocaine-Related Disorders Heart Rate Internal medicine Neural Pathways Injury prevention medicine Humans Drug craving Sex Characteristics Neural correlates of consciousness Hyperactivation Functional Neuroimaging Brain medicine.disease Magnetic Resonance Imaging Behavior Addictive Substance abuse Psychiatry and Mental health Endocrinology Female Cues Psychology Stress Psychological Sex characteristics Clinical psychology |
| Zdroj: | American Journal of Psychiatry. 169:406-414 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/appi.ajp.2011.11020289 |
| Popis: | Although stress and drug cue exposure each increase drug craving and contribute to relapse in cocaine dependence, no previous research has directly examined the neural correlates of stress-induced and drug cue-induced craving in cocaine-dependent women and men relative to comparison subjects.Functional MRI was used to assess responses to individualized scripts for stress, drug/alcohol cue and neutral-relaxing-imagery conditions in 30 abstinent cocaine-dependent individuals (16 women, 14 men) and 36 healthy recreational-drinking comparison subjects (18 women, 18 men).Significant three-way interactions between diagnostic group, sex, and script condition were observed in multiple brain regions including the striatum, insula, and anterior and posterior cingulate. Within women, group-by-condition interactions were observed involving these regions and were attributable to relatively increased regional activations in cocaine-dependent women during the stress and, to a lesser extent, neutral-relaxing conditions. Within men, group main effects were observed involving these same regions, with cocaine-dependent men demonstrating relatively increased activation across conditions, with the main contributions from the drug and neutral-relaxing conditions. In men and women, subjective drug-induced craving measures correlated positively with corticostriatal-limbic activations.In cocaine dependence, corticostriatal-limbic hyperactivity appears to be linked to stress cues in women, drug cues in men, and neutral-relaxing conditions in both. These findings suggest that sex should be taken into account in the selection of therapies in the treatment of addiction, particularly those targeting stress reduction. |
| Databáze: | OpenAIRE |
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