Estimating transmission parameters of F4 + E. coli for F4-receptor-positive and -negative piglets: one-to-one transmission experiment

Autor: Annemarie Bouma, P. L. Geenen, J. van der Meulen, M.C.M. de Jong
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Male
Swine
Epidemiology
animal diseases
Kwantitatieve Veterinaire Epidemiologie
medicine.disease_cause
Disease Outbreaks
law.invention
fluids and secretions
law
Receptor
weaned pigs
Escherichia coli Infections
Adhesins
Escherichia coli
education.field_of_study
integumentary system
Escherichia coli Proteins
k88
phenotypes
small-intestine
Infectious Diseases
medicine.anatomical_structure
Transmission (mechanics)
Fimbriae Proteins
Research Article
ID - Infectieziekten
Secondary infection
Population
prevalence
postweaning diarrhea
Biology
Microbiology
resistance
Escherichia coli
medicine
Animals
Serotyping
education
Glycoproteins
Antigens
Bacterial
Inoculation
Outbreak
Quantitative Veterinary Epidemiology
edema disease
bacterial infections and mycoses
pseudorabies virus
Immunity
Innate
Small intestine
Animals
Newborn
f-18
WIAS
ID - Dier en Omgeving
Zdroj: Epidemiology and Infection, 132(6), 1039-1048
Epidemiology and Infection 132 (2004) 6
ISSN: 0950-2688
Popis: F4+ Escherichia coli is an important agent of post-weaning diarrhoea in piglets. Piglets that express an adhesion site for F4+ E. coli in their small intestine (F4R+) shed higher numbers of F4+ E. coli than piglets lacking this site (F4R−). We hypothesized that F4R+ piglets are more infectious and more susceptible for F4+ E. coli. This implies that in populations with F4R+ and F4R− piglets, the transmission would be dependent on the frequency of both types of animals. To quantify the difference in infectiousness and susceptibility, a one-to-one transmission experiment was performed with 20 pairs consisting of one inoculated and one contact piglet. Based on the contact infections observed, transmission parameters were estimated with generalized linear models. F4R+ piglets were infectious for other piglets and the reproduction ratio (R0) for homogeneous F4R+ populations, that is the average number of secondary infections that one F4R+ pig will cause during its entire infectious period in a population of susceptible F4R+ individuals only, was estimated as 7·1. F4R+ piglets were more susceptible than F4R− piglets and reducing the fraction of F4R+ piglets of a population will reduce transmission. It was calculated that in order to prevent major outbreaks of F4+ E. coli (R0
Databáze: OpenAIRE
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