Dependence of Thyroid Sonographic Markers of Malignancy and Its Influence on the Diagnostic Value of Sonographic Findings
| Autor: | Ewelina Szczepanek-Parulska, Adam Stangierski, Edyta Gurgul, Kosma Woliński, Marek Ruchała |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Thyroid nodules medicine.medical_specialty Goiter Article Subject medicine.medical_treatment Risk of malignancy Thyroid Gland lcsh:Medicine Malignancy General Biochemistry Genetics and Molecular Biology Cohort Studies Predictive Value of Tests Humans Medicine Thyroid Neoplasms Thyroid Nodule Ultrasonography General Immunology and Microbiology business.industry lcsh:R Thyroid Thyroidectomy Echogenicity General Medicine Middle Aged medicine.disease medicine.anatomical_structure Predictive value of tests Female Radiology business Biomarkers Research Article Goiter Nodular |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Introduction. Thyroid nodules constitute frequent medical condition. Ultrasonographic (US) examination remains the basis in the diagnostics of nodular goiter and selection of the suspected ones requiring fine-needle aspiration biopsy (FNAB). The aim of this study was to evaluate if the features so far considered to be US malignancy markers are dependent or independent variables and to check if these data are clinically relevant.Materials and Methods. Patients with diagnosed thyroid nodular goiter admitted for thyroidectomy, irrespectively of the indications for surgery, were involved. The following parameters were assessed: echogenicity, the presence of calcifications, presence of halo, shape, margins, structure (solid, partially or pure cystic), and elasticity of the nodules (assessed quantitatively).Results. 122 consecutive patients with 393 thyroid nodules were included. There were significant associations between halo absence and irregular borders, micro- and macrocalcifications, taller-than-wide feature and macrocalcifications, irregular margins and macrocalcifications, and also decreased elasticity of nodules and several attributes (partially cystic character, micro- and macrocalcifications).Conclusions. Not only diagnostic value of particular sonographic features but also data about cooccurrence and associations between them are clinically relevant. Although most of these features turned out to be independent, omitting significant association can lead to incorrect assessment of the risk of malignancy. |
| Databáze: | OpenAIRE |
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