High risk of peripheral arterial disease in the United Kingdom: 2-year results of a prospective registry
| Autor: | Gerry Fowkes, Marcus Flather, Prepared (Prospective Registry), Julie Brittenden, Distribution Investigators, Rebecca Mister, Simon Ashley, F. Nugara, Gerard Stansby, Cliff Shearman, Michael Roughton, Ray Hannon, Andrew W. Bradbury |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Peripheral Arterial Disease Risk Factors Internal medicine Diabetes mellitus medicine Ambulatory Care Humans cardiovascular diseases Myocardial infarction Prospective Studies Registries Risk factor Prospective cohort study Stroke Aged business.industry Cardiovascular Agents Intermittent Claudication Middle Aged medicine.disease Intermittent claudication United Kingdom Surgery Survival Rate Blood pressure Female medicine.symptom Cardiology and Cardiovascular Medicine business Claudication |
| Zdroj: | Angiology. 62(2) |
| ISSN: | 1940-1574 |
| Popis: | We report a prospective 2-year, multicenter study of patients presenting with intermittent claudication (IC; ankle brachial blood pressure index, ABPI ≤ 0.9). Mean age of the 473 patients enrolled was 68 years, 20% were diabetics, 30% had prior symptomatic coronary heart disease (CHD), 7% had prior stroke, and 39% were current smokers. At baseline, 26.2% of patients had BP ≤ 140/85 mm Hg or lower and at 2 years this figure was 32.5% (P = .01). Current smokers had fallen to 27% (from 39%) at 2 years (P < .001). Use of antiplatelet agents, statins, and angiotensin converting enzyme inhibitors increased significantly during the course of the study as did claudication distance. Death and the composite of death, stroke or myocardial infarction (MI), occurred in 8.4% and 11.6% of patients, respectively. Prognosis was worse in patients with prior history of CHD, older age, those with diabetes and a lower ABPI. |
| Databáze: | OpenAIRE |
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