iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility
| Autor: | Daniel J. Pennington, S. Murtough, Najwa Zaman, Diana C. Blaydon, Jennifer Chao-Chu, David P. Kelsell |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Keratinocytes Esophageal Neoplasms Regulator RHBDF2 Dermatitis Dermatology Biology ADAM17 Protein Keratin 16 Biochemistry 03 medical and health sciences Mice 0302 clinical medicine Keratoderma Palmoplantar medicine Animals Humans Molecular Biology Mice Knockout integumentary system Host Microbial Interactions Foot Rhomboid Tumor Suppressor Proteins Intracellular Signaling Peptides and Proteins Signal transducing adaptor protein Cell Biology Sheddase medicine.disease Hand stomatognathic diseases Disease Models Animal 030104 developmental biology Palmoplantar keratoderma medicine.anatomical_structure Gene Expression Regulation 030220 oncology & carcinogenesis Mutation Skin Diseases Viral Perspective Cancer research Keratins Epidermis Keratinocyte Carrier Proteins Signal Transduction Transcription Factors |
| Zdroj: | The Journal of Investigative Dermatology |
| ISSN: | 1523-1747 |
| Popis: | The palmoplantar epidermis is a specialized area of the skin that undergoes high levels of mechanical stress. The palmoplantar keratinization and esophageal cancer syndrome, tylosis with esophageal cancer, is linked to mutations in RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2. Subsequently, iRhom2 was found to affect palmoplantar thickening to modulate the stress keratin response and to mediate context-dependent stress pathways by p63. iRhom2 is also a direct regulator of the sheddase, ADAM17, and the antiviral adaptor protein, stimulator of IFN genes. In this perspective, the pleiotropic functions of iRhom2 are discussed with respect to the skin, inflammation, and the antiviral response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|