Hyperalgesia after a Drinking Episode in Young Adult Binge Drinkers: A Cross-Sectional Study
| Autor: | Hunter Hahn, Thomas H. Welsh, Mary W. Meagher, Dokyoung S. You |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Epinephrine Hydrocortisone Cross-sectional study Physiology Binge drinking Article Binge Drinking 03 medical and health sciences Young Adult 0302 clinical medicine Surveys and Questionnaires Threshold of pain medicine Humans Young adult business.industry General Medicine Substance Withdrawal Syndrome 030104 developmental biology Cross-Sectional Studies Hyperalgesia Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug Hormone Follow-Up Studies |
| Zdroj: | Alcohol Alcohol |
| Popis: | Aims Rodent studies propose potential mechanisms linking excessive drinking and pain hypersensitivity (hyperalgesia), such that stress hormones (i.e. epinephrine and cortisol) mediate induction and maintenance of alcohol withdrawal-induced hyperalgesia. The first aim of this study was to examine whether hyperalgesia would occur within 48 h after a drinking episode in healthy young adult binge drinkers. The second was to examine whether stress hormones and negative effect would be associated with binge drinking or alcohol withdrawal-associated hyperalgesia. Methods A cross-sectional experiment was conducted in five groups with naturally occurring drinking (mean age = 19.6, range 18–29 years): abstainers (n = 43, 54% female), moderate drinkers with (n = 50, 50% female) or without recent drinking (i.e. within 48 h, n = 23, 26% female) and binge drinkers with (n = 36, 58% female) or without recent drinking (n = 25, 44% female). All types of drinkers endorsed drinking about 2–3 times a month and 2–3 years of drinking history. Results Muscle pressure pain thresholds were significantly lower in the binge group with recent drinking compared to other groups, but cutaneous mechanical and heat pain thresholds were not significantly different across the five groups. Basal epinephrine levels were significantly higher in binge groups regardless of recent drinking, but cortisol and negative effect were not significantly different across the five groups. Conclusions This is the first study to show that alcohol withdrawal-associated muscle hyperalgesia may occur in healthy episodic binge drinkers with only 2–3 years of drinking history, and epinephrine may play a role in binge drinking-associated hyperalgesia. |
| Databáze: | OpenAIRE |
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