Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep
| Autor: | Patrick E. Matthews, Peter J. Hudson, David J. Páez, Kimberly R. Andrews, Lisette P. Waits, E. Frances Cassirer, Raina K. Plowright, Thomas E. Besser, Kezia R. Manlove |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine medicine.medical_specialty Range (biology) Population Sheep Diseases Animals Wild Disease 010603 evolutionary biology 01 natural sciences 03 medical and health sciences Mycoplasma ovipneumoniae Pneumonia Mycoplasma medicine Animals education Ecology Evolution Behavior and Systematics education.field_of_study Sheep biology Ecology business.industry Public health symbols.heraldic_supporter Sheep Bighorn Pneumonia medicine.disease biology.organism_classification 030104 developmental biology Immunology symbols Livestock business Pneumonia (non-human) Ovis canadensis |
| Zdroj: | Ecology Letters. 20:1325-1336 |
| ISSN: | 1461-023X |
| DOI: | 10.1111/ele.12829 |
| Popis: | Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free-ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age-structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation. |
| Databáze: | OpenAIRE |
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