Continuous Intravenous Infusion of Small Doses of Insulin in Treatment of Diabetic Ketoacidosis
| Autor: | P. F. Semple, C. White, W. G. Manderson |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Diabetic ketoacidosis medicine.medical_treatment Loading dose Diabetic Ketoacidosis Internal medicine medicine Humans Insulin Arterial pH Infusions Parenteral In patient Aged Diabetic Coma General Environmental Science business.industry General Engineering Papers and Originals General Medicine Hydrogen-Ion Concentration Ketones Middle Aged medicine.disease Regimen Glucose Endocrinology Hyperglycemia Potassium General Earth and Planetary Sciences Female Ketosis business Diabetic coma |
| Zdroj: | BMJ. 2:694-698 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.2.5921.694 |
| Popis: | Continuous intravenous infusion of small amounts of insulin has been used in the management of a series of patients with diabetic ketoacidosis. In 13 patients with a plasma glucose level on admission of 725 mg/100 ml (+/- 80 S.E. of mean) and an arterial pH of 7.07 +/- 0.05 a mean loading dose of 6.5 +/- 0.82 units of soluble insulin was administered intravenously, and thereafter a sustaining infusion of 6.5 +/- 0.82 U/hr was continued until ketosis was corrected and the plasma glucose fell below 300 mg/100 ml. The total insulin dose needed to achieve this was 39.2 +/- 6.6 units given over a 3 to 10-hour period. Plasma insulin was measured in patients who had not previously received insulin and the mean level at an infusion rate of 4 U/hr was 75.6 +/- 8.0 muU/ml. Plasma glucose fell at a regular rate of 101 +/- 11 mg/100 ml/hr, and ketosis improved in parallel. Plasma potassium was well maintained throughout treatment. This regimen of treatment was clinically effective and simple to follow. |
| Databáze: | OpenAIRE |
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