Correlation of Macular Sensitivity Measures and Visual Acuity to Vision-related Quality of Life in Patients with Age-related Macular Degeneration
| Autor: | Alexandra Kalia Parpounas, Torben Lykke Sørensen, Thomas Richard Johansen Forshaw |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Macular sensitivity
medicine.medical_specialty Visual acuity genetic structures Vision-related quality of life Visual Acuity Retina Microperimetry Correlation Macular Degeneration 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Quality of life Age related Ophthalmology Humans Medicine Macula Lutea In patient business.industry Age-related macular degeneration General Medicine Diabetic retinopathy Macular degeneration Early treatment diabetic retinopathy study medicine.disease Visual function questionnaire 39 eye diseases lcsh:RE1-994 Quality of Life 030221 ophthalmology & optometry sense organs medicine.symptom business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Ophthalmology, Vol 21, Iss 1, Pp 1-11 (2021) Forshaw, T R J, Parpounas, A K & Sørensen, T L 2021, ' Correlation of macular sensitivity measures and visual acuity to vision-related quality of life in patients with age-related macular degeneration ', BMC Ophthalmology, vol. 21, 149 . https://doi.org/10.1186/s12886-021-01901-x BMC Ophthalmology |
| DOI: | 10.21203/rs.2.21263/v3 |
| Popis: | Background Visual acuity is commonly used as a functional outcome measure in patients with age-related macular degeneration (AMD), despite having a weak correlation with self-perceived visual quality of life. Microperimetry is a useful method of detecting loss of macular function. We wanted to investigate the relationship between these two objective visual outcome measures and subjective vision-related quality of life, finding out which objective measure is more patient-relevant. Methods Fifty-one consecutive patients with AMD were recruited to the study. Participants were required to complete the Visual Function Questionnaire 39, the Early Treatment Diabetic Retinopathy Study visual acuity examination and a microperimetry assessment using the Micro Perimeter 3. One patient withdrew consent and seven patients dropped out due to cooperation difficulties under microperimetry. Forty-three patients with AMD were included in the study: twenty-eight patients with late AMD (exudative AMD) and fifteen patients with early (non-exudative) AMD. The right eye was included as standard, as was the eye with the best-corrected visual acuity. Results There was a higher correlation between vision-related quality of life and macular sensitivity (r = 0.458; p = 0.014) than between vision-related quality of life and visual acuity (r = 0.446; p = 0.018) in patients with late AMD. There was a positive correlation between vision-related quality of life and macular sensitivity in patients with early AMD (r = 0.542; p = 0.037) while the correlation between vision-related quality of life and visual acuity in these patients was not statistically significant. Composite score (r = 0.469; p = 0.012) correlated highest with the nasal outer macular sub-region and near-distance activities score (r = 0.652; p p = 0.012). Conclusions Macular sensitivity as measured using microperimetry correlates with vision-related quality of life in early AMD and in late AMD, showing it to be a patient-relevant outcome measure. Furthermore, the nasal sub-regions of the macula appear to be preferred retinal loci in patients with AMD. (338 words) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|