ZCCHC12, a novel oncogene in papillary thyroid cancer
| Autor: | Zhou-Ci Zheng, Xiaohua Zhang, Wen-Xu Jin, Ouchen Wang, Yinghao Wang, Endong Chen, Qing-Xuan Wang, Yi-Xiang Jin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty endocrine system diseases Malignancy medicine.disease_cause Sensitivity and Specificity Papillary thyroid cancer 03 medical and health sciences 0302 clinical medicine Gentamicin protection assay Internal medicine Biomarkers Tumor medicine Humans Thyroid Neoplasms Thyroid cancer Aged Hematology Oncogene business.industry Thyroid Oncogenes General Medicine Middle Aged medicine.disease Carcinoma Papillary 030104 developmental biology medicine.anatomical_structure Thyroid Cancer Papillary Lymphatic Metastasis 030220 oncology & carcinogenesis Female business Carcinogenesis Transcription Factors |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 143:1679-1686 |
| ISSN: | 1432-1335 0171-5216 |
| Popis: | Thyroid cancer is the most common endocrine malignancy worldwide. The molecular mechanisms underlying thyroid tumorigenesis remain unclear. Some studies suggested that the ZCCHC12 gene correlates with certain diseases. However, the function of ZCCHC12 in thyroid cancer has yet to be determined. This study investigated the role of the ZCCHC12 gene in papillary thyroid cancer (PTC). We conducted a comprehensive analysis of massively parallel whole-transcriptome resequencing of matched PTC tumors and normal tissues in 19 patients. Results showed that the expression of ZCCHC12 was significantly upregulated in thyroid cancer. qRT-PCR was performed to confirm previous results. The functions of the ZCCHC12 gene in PTC cell lines (TPC1 and BCPAP) transfected with small interfering RNA were determined through cell colony formation assay, migration assay, and invasion assay. The ZCCHC12 gene was remarkably upregulated in primary PTC tumors in both validated cohort (T:N = 1.80 ± 2.58:0.23 ± 0.50, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink