Evaluation of MAGNet, a long-lasting insecticidal mosquito net against Anopheles fluviatilis in experimental huts in India

Autor: Subramanian Swaminathan, Gunasekaran Kasinathan, Manju Rahi, Jambulingam Purushothaman, Vijayakumar Tharmalingam, Sudhansu Sekhar Sahu
Rok vydání: 2019
Předmět:
Zdroj: Malaria Journal, Vol 18, Iss 1, Pp 1-8 (2019)
Malaria Journal
ISSN: 1475-2875
DOI: 10.1186/s12936-019-2692-3
Popis: Background MAGNet LN is a wash resistant long-lasting insecticidal (polyethylene) net (LLIN) in which the alpha-cypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of the nets. The bio-efficacy of MAGNet LN was reported to be high even after 25 washes. The LN met the WHO criteria of Phase I evaluation and obtained recommendation from the World Health Organization Pesticide Evaluation Scheme (WHOPES) for Phase II trial. For registration of the LN in India, the current study was conducted to evaluate its efficacy after 20 or 25 washes compared to negative control (untreated net) and positive control (Duranet LN) in experimental huts against a wild, free flying pyrethroid susceptible population of Anopheles fluviatilis in terms of deterrence, blood-feeding inhibition, mortality and induced exophily. Methods The evaluation was carried out in six experimental huts located at Kandhaguda village in Malkangiri district, Odisha state following the WHO guidelines. Results The study showed that 25 times washed MAGNet LN produced 100% mortality in cone bioassays before and after hut evaluation. MAGNet washed 25 times did not differ significantly from all other treated nets in terms of deterring hut entry, induced exophily, blood feeding inhibition and causing mortality of An. fluviatilis. Conclusions MAGNet LN showed extended wash resistance retaining its bio-efficacy up to 25 washes and met the WHOPES requirement of passing Phase II evaluation. Electronic supplementary material The online version of this article (10.1186/s12936-019-2692-3) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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