Prevalence of hepatitis C infection and its associated factors in healthy adults without identifiable route of transmission
| Autor: | Siu Cheung Ng, Denise P. Chan, Cheuk-Kwong Lee, Hoi Kei Wong, Ngai Sze Wong, Shui Shan Lee |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood transfusion Genotype Sexual Behavior medicine.medical_treatment Hepatitis C virus Blood Donors Hepacivirus medicine.disease_cause World health 03 medical and health sciences Body piercing 0302 clinical medicine Risk Factors Virology Internal medicine Prevalence Humans Medicine Blood Transfusion 030212 general & internal medicine Substance Abuse Intravenous Genotyping Aged Hepatology business.industry Transmission (medicine) interests Transfusion Reaction Hepatitis C Hepatitis C Antibodies Middle Aged medicine.disease Healthy Volunteers Infectious Diseases Case-Control Studies Immunology Hong Kong RNA Viral Female 030211 gastroenterology & hepatology business Intramuscular injection interests.hobby |
| Zdroj: | Journal of Viral Hepatitis. 25:161-170 |
| ISSN: | 1352-0504 |
| DOI: | 10.1111/jvh.12804 |
| Popis: | Summary While hepatitis C virus (HCV) infection is long known to be associated with parenteral exposure, the specific route of transmission is not identified in a proportion of infected patients. Taking blood donors as the surrogate of healthy adults in the community in Hong Kong, we identified 91 HCV-infected donors (≤0.02% positive rate) in 2014-2016, of whom 46 were recruited in a mixed-method study to examine their transmission routes. A majority (75%) of the recruited donors were HCV RNA positive, with the predominant subtypes being 1b and 6a. From the results of the structured self-administered questionnaire and in-depth interviews, only 14 (30%) recruited donors could be traced to past history of contaminated blood transfusion (n = 9) or injection drug use (n = 5). Case-control analyses with 3 different control groups were performed to examine factors associated with HCV infection in multivariable analyses. High-risk sexual behaviour, body piercing, intramuscular injection and vaccine inoculation abroad, having lived abroad for >3 months were significantly associated with HCV in donors with otherwise nonidentifiable source of infection. While the specific route of transmission cannot be established for each person, associations with multiple parenteral exposures outside Hong Kong were observed. The World Health Organization has advocated for the global elimination of HCV by 2030. With a high proportion of HCV-infected persons who are unaware of their infections, HCV elimination could be hard to achieve. |
| Databáze: | OpenAIRE |
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