Diabetic hearts have lower basal urocortin levels that fail to increase after cardioplegic arrest: Association with increased apoptosis and postsurgical cardiac dysfunction

Autor: Anastasis Stephanou, Tiziano M. Scarabelli, Carol Chen-Scarabelli, Louis D. Saravolatz, Gabriele Scarabelli, Alessandro Mazzucco, Maddalena Tessari, Francesco Onorati, Giuseppe Faggian, Richard A. Knight, Jagat Narula, Alessio Rungatscher
Rok vydání: 2014
Předmět:
Male
Time Factors
Biopsy
Apoptosis
Coronary Artery Disease
Mitochondria
Heart
law.invention
MELLITUS
Basal (phylogenetics)
law
Myocyte
Myocytes
Cardiac
PROTECTION
Myocardial infarction
Coronary Artery Bypass
Urocortins
Urocortin
CARDIOPULMONARY BYPASS
Middle Aged
ADENOSINE
CORTICOTROPIN-RELEASING-FACTOR
Protein Kinase C-delta
Protein Transport
Treatment Outcome
Heart Arrest
Induced
Cardiology
Female
Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Protein Kinase C-epsilon
HYPERGLYCEMIA
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Cardiopulmonary bypass
Humans
Heart Atria
RNA
Messenger
Protein kinase C
Aged
COLD STATIC STORAGE
GRAFT-SURGERY
business.industry
MORTALITY
Troponin I
CORONARY-ARTERY-BYPASS
CORTICOTROPIN-RELEASING-FACTOR
COLD STATIC STORAGE
GRAFT-SURGERY
CARDIOPULMONARY BYPASS
MORTALITY
MELLITUS
ADENOSINE
HYPERGLYCEMIA
PROTECTION
medicine.disease
CORONARY-ARTERY-BYPASS
Surgery
business
Biomarkers
Zdroj: The Journal of Thoracic and Cardiovascular Surgery. 148(5):2296-2308
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2014.05.018
Popis: ObjectivesThe present study investigated the cardioprotective role of urocortin (Ucn) and its relationship with protein kinase C (PKC)ε and PKCδ in patients with (DMPs) and without (NDMPs) diabetes mellitus after on-pump cardiac surgery (OPCS). The molecular mechanisms responsible for the reported worse outcomes of DMP after OPCS remain unknown.MethodsTwo sequential biopsy specimens were obtained from the right atrium of 27 DMPs and 22 NDMPs before and after cardiopulmonary bypass.ResultsPostcardioplegic induction of Ucn in NDMPs (P
Databáze: OpenAIRE
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