Risk factors for longitudinal changes in left ventricular diastolic function among women and men
| Autor: | Jan-Kees van den Berge, Jaap W. Deckers, M. Arfan Ikram, Luis E. Echeverría, Oscar L. Rueda-Ochoa, Dimitris Rizopoulos, Oscar H. Franco, Klodian Dhana, Maryam Kavousi, Marco A Smiderle-Gelain |
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| Přispěvatelé: | Epidemiology, Cardiology |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Time Factors sex difference Cardiovascular risk factors Population Doppler echocardiography Risk Assessment Ventricular Function Left Rotterdam Study Ventricular Dysfunction Left Sex Factors Diastole Risk Factors Internal medicine Diabetes mellitus medicine Diabetes Mellitus cohort study Humans Diastolic function Longitudinal Studies Obesity Prospective Studies left ventricular diastolic function education Heart Failure and Cardiomyopathies Aged Dyslipidemias Netherlands education.field_of_study medicine.diagnostic_test business.industry Smoking Middle Aged medicine.disease Cardiology Female Cardiology and Cardiovascular Medicine business Body mass index echocardiography doppler Cohort study |
| Zdroj: | Heart Heart, 105(18), 1414-1422. BMJ Publishing Group |
| ISSN: | 1468-201X 1355-6037 |
| Popis: | ObjectiveTo evaluate changes in left ventricular diastolic function (LVDF) parameters and their associated risk factors over a period of 11 years among community-dwelling women and men.MethodsEchocardiography was performed three times among 870 women and 630 men (age 67±3 years) from the prospective population-based Rotterdam Study during a period of 11-year follow-up. Changes in six continuous LVDF parameters were correlated with cardiovascular risk factors using a linear-mixed effect model (LMM).ResultsIn women, smoking was associated with deleterious longitudinal changes in deceleration time (DT) (Beta (β): 7.73; 95% CI 2.56 to 12.9) and high-density lipoprotein cholesterol was associated with improvement of septal e′ (β: 0.37; 95% CI 0.13 to 0.62) and E/e′ ratio (β: −0.46; 95% CI −0.84 to –0.08) trajectories. Among men, diabetes was associated with deleterious longitudinal changes in A wave (β: 3.83; 95% CI 0.06 to 7.60), septal e′ (β: −0.40; 95% CI −0.70 to –0.09) and E/e′ ratio (β: 0.60; 95% CI 0.14 to 1.06) and body mass index was associated with deleterious longitudinal changes in A wave (β: 1.25; 95% CI 0.84 to 1.66), E/A ratio (β: −0.007; 95% CI −0.01 to –0.003), DT (β: 0.86; 95% CI 0.017 to 1.71) and E/e′ ratio (β: 0.12; 95% CI 0.06 to 0.19).ConclusionsSmoking among women and metabolic factors (diabetes mellitus and body mass index) among men showed larger deleterious associations with longitudinal changes in LVDF parameters. The favourable association of HDL was mainly observed among women. This study, for the first time, evaluates risk factors associated with changes over time in continuous LVDF parameters among women and men and generates new hypothesis for further medical research. |
| Databáze: | OpenAIRE |
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