RANKL induces organized lymph node growth by stromal cell proliferation
| Autor: | S. Lori Bridal, Marion Decossas, Sylvestre Chea, Vincent Duheron, Yongwon Choi, Mattéo R. Bosisio, Frédéric Lézot, Rachel Golub, Christopher G. Mueller, Ariane Berdal, Estelle Hess, Hideo Yagita |
|---|---|
| Přispěvatelé: | Immunologie et chimie thérapeutiques (ICT), Cancéropôle du Grand Est-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Lymphopoïèse, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Imagerie Paramétrique (LIP), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR58-Centre National de la Recherche Scientifique (CNRS), ECHOSENS S.A., Echosens, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Department of Immunology, Juntendo University School of Medicine, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Pennsylvania [Philadelphia], Immunologie et chimie thérapeutiques ( ICT ), Cancéropôle du Grand Est-Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche des Cordeliers ( CRC (UMR_S 872) ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire d'Imagerie Paramétrique ( LIP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR58-Centre National de la Recherche Scientifique ( CNRS ), Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
MESH: Chemokine CCL19
MESH: Lymph Nodes MESH : Hair Follicle Mice 0302 clinical medicine MESH : Cell Proliferation Homeostasis [ SDV.IMM ] Life Sciences [q-bio]/Immunology Immunology and Allergy MESH: Animals Lymph node MESH : Lymph Nodes 0303 health sciences MESH: RANK Ligand MESH : Mice Transgenic MESH : Chemokine CXCL13 Cell biology medicine.anatomical_structure Lymphatic system RANKL MESH: Homeostasis MESH : Homeostasis [SDV.IMM]Life Sciences [q-bio]/Immunology MESH: Hair Follicle MESH : RANK Ligand MESH: Chemokine CXCL13 Hair Follicle Stromal cell MESH: Mice Transgenic Immunology Mice Transgenic Biology 03 medical and health sciences MESH: Cell Proliferation MESH : Mice medicine Lymph node stromal cell Animals CXCL13 MESH: Mice B cell Cell Proliferation 030304 developmental biology MESH: Immune System RANK Ligand Hair follicle Chemokine CXCL13 MESH : Chemokine CCL19 Immune System MESH : Stromal Cells MESH : Immune System biology.protein Chemokine CCL19 Lymph Nodes MESH : Animals Stromal Cells MESH: Stromal Cells 030215 immunology |
| Zdroj: | Journal of Immunology Journal of Immunology, 2012, 188 (3), pp.1245-54. ⟨10.4049/jimmunol.1101513⟩ Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2012, 188 (3), pp.1245-54. ⟨10.4049/jimmunol.1101513⟩ Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2012, 188 (3), pp.1245-54. 〈10.4049/jimmunol.1101513〉 |
| ISSN: | 0022-1767 1550-6606 |
| DOI: | 10.4049/jimmunol.1101513⟩ |
| Popis: | RANK and its ligand RANKL play important roles in the development and regulation of the immune system. We show that mice transgenic for Rank in hair follicles display massive postnatal growth of skin-draining lymph nodes. The proportions of hematopoietic and nonhematopoietic stromal cells and their organization are maintained, with the exception of an increase in B cell follicles. The hematopoietic cells are not activated and respond to immunization by foreign Ag and adjuvant. We demonstrate that soluble RANKL is overproduced from the transgenic hair follicles and that its neutralization normalizes lymph node size, inclusive area, and numbers of B cell follicles. Reticular fibroblastic and vascular stromal cells, important for secondary lymphoid organ formation and organization, express RANK and undergo hyperproliferation, which is abrogated by RANKL neutralization. In addition, they express higher levels of CXCL13 and CCL19 chemokines, as well as MAdCAM-1 and VCAM-1 cell-adhesion molecules. These findings highlight the importance of tissue-derived cues for secondary lymphoid organ homeostasis and identify RANKL as a key molecule for controlling the plasticity of the immune system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|