Low Helicobacter pylori eradication rates with 4- and 7-day regimens in an Iranian population
| Autor: | Masoud Babaei, Javad Mikaeli, Ali Majidpour, Shahab Dolatshahi, Rasoul Sotoudemanesh, Shahnam Arshi, Abbas Yazdanbod, Shahin Merat, Masoud Sotoudeh, Akram Pourshams, Reza Malekzadeh, M J Farahvash, Siavosh Nasseri-Moghaddam, Farideh Siavoshi, Mohammad-Hassan Derakhshan, Behnoosh Abedi |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Chronic gastritis Rapid urease test Iran Gastroenterology Drug Administration Schedule Helicobacter Infections Internal medicine Clarithromycin Medicine Humans Omeprazole Antibacterial agent Aged Hepatology biology Helicobacter pylori business.industry Amoxicillin Middle Aged medicine.disease biology.organism_classification Anti-Bacterial Agents Metronidazole Drug Combinations Treatment Outcome Female business medicine.drug |
| Zdroj: | Journal of gastroenterology and hepatology. 18(1) |
| ISSN: | 0815-9319 |
| Popis: | Background: In Iran, there is insufficient information on the efficacy of Helicobacter pylori eradication regimens shorter than 10 days. This study aims at assessing the efficacy of 4- and 7-day H. pylori eradication regimens in a high-incidence area of gastric cancer in Iran. Methods: Subjects with an endoscopic diagnosis of gastritis, positive urease test, and a histological diagnosis of chronic gastritis were enrolled. Patients were randomly assigned to one of three groups: AOC7 (1000 mg amoxicillin, 20 mg omeprazole, and 500 mg clarithromycin twice daily for 7 days), FOT4 (200 mg furazolidone, 20 mg omeprazole, and 500 mg tetracycline twice daily for 4 days) and FOT7 (the same treatment as the FOT4 group but for 7 days). Sensitivity to these antibiotics was determined in all isolates recovered from culture. The efficacy of eradication was assessed 8 weeks after the end-of-treatment by the 14C-urea breath test. Results: One hundred and twenty-eight patients were enrolled in the study. Culture was positive for 84 patients and none of these were resistant to amoxicillin, tetracycline or furazolidone, 1.2% were resistant to clarithromycin and 32.1% to metronidazole. Forty-five, 41 and 42 patients were randomly allocated to the AOC7, FOT4, and FOT7 groups, respectively. The intention-to-treat eradication rates were 35.5, 17.1, and 23.8% for the AOC7, FOT4, and FOT7 groups, respectively. Conclusion: Treatment regimens of 4 or 7 days are unacceptable for H. pylori infection in Iran, even in the presence of a favorable sensitivity profile. © 2003 Blackwell Publishing Asia Pty Ltd |
| Databáze: | OpenAIRE |
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