Reocclusion prophylaxis with dipyridamole combined with acetylsalicylic acid following PTA
| Autor: | H.W. Heiss, D. Middleton, H. Just, G. Deichsel |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_treatment Acide acétylsalicylique 030204 cardiovascular system & hematology Group comparison Placebo Placebo group 03 medical and health sciences 0302 clinical medicine Double-Blind Method Fibrinolytic Agents Recurrence medicine Humans Popliteal Artery 030212 general & internal medicine Vascular Patency Aged Randomized Controlled Trials as Topic Aged 80 and over Chemotherapy Aspirin business.industry Low dose Significant difference Arteriosclerosis Obliterans Dipyridamole Middle Aged Femoral Artery Radiography Anesthesia Female Cardiology and Cardiovascular Medicine business Angioplasty Balloon medicine.drug |
| Zdroj: | Angiology. 41(4) |
| ISSN: | 0003-3197 |
| Popis: | After primary successful PTA, 199 patients were randomized into one of three treatment groups, namely, placebo or a combination of 75 mg dipyridamole with either 330 mg (high dose) or 100 mg (low dose) acetylsalicylic acid (ASA) tid. The duration of treatment was six months. Of the 199 patients admitted to the study, 156 completed the six-month trial period. Not all patients had a second angiogram, and in these cases clinical findings were used in the evaluation. Evaluation of the combined angiographic and clinical results showed improvement or no deterioration in 37% of patients in the placebo group compared with 49% in the low-dose and 61% in the high-dose ASA groups respectively. The only statistically significant difference observed was between the placebo group and the group treated with dipyridamole and high-dose ASA (p = 0.01). This difference remained statistically significant at p = 0.039 if only the angiographic findings were considered for group comparison. It cannot, however, be concluded from this study that 75 mg dipyridamole in combination with 100 mg ASA tid is more effective in preventing reocclusion after PTA than in combination with 330 mg ASA tid. |
| Databáze: | OpenAIRE |
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