Increased Intrinsic Connectivity of the Default Mode Network in Temporal Lobe Epilepsy: Evidence from Resting-State MEG Recordings
| Autor: | Shang Yeong Kwan, Chun Hing Yiu, Chien Chen, Fu Jung Hsiao, Yung Yang Lin, Wei Ta Chen, Der Jen Yen, Yang Hsin Shih, Hsiang Yu Yu |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male lcsh:Medicine Electroencephalography Biology behavioral disciplines and activities Lateralization of brain function Temporal lobe medicine Humans Ictal lcsh:Science Default mode network Brain Mapping Multidisciplinary Resting state fMRI medicine.diagnostic_test lcsh:R Magnetoencephalography nervous system diseases nervous system Epilepsy Temporal Lobe lcsh:Q Female Nerve Net Functional magnetic resonance imaging Neuroscience human activities psychological phenomena and processes Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 6, p e0128787 (2015) |
| ISSN: | 1932-6203 |
| Popis: | The electrophysiological signature of resting state oscillatory functional connectivity within the default mode network (DMN) during spike-free periods in temporal lobe epilepsy (TLE) remains unclear. Using magnetoencephalographic (MEG) recordings, this study investigated how the connectivity within the DMN was altered in TLE, and we examined the effect of lateralized TLE on functional connectivity. Sixteen medically intractable TLE patients and 22 controls participated in this study. Whole-scalp 306-channel MEG epochs without interictal spikes generated from both MEG and EEG data were analyzed using a minimum norm estimate (MNE) and source-based imaginary coherence analysis. With this processing, we obtained the cortical activation and functional connectivity within the DMN. The functional connectivity was increased between DMN and the right medial temporal (MT) region at the delta band and between DMN and the bilateral anterior cingulate cortex (ACC) regions at the theta band. The functional change was associated with the lateralization of TLE. The right TLE showed enhanced DMN connectivity with the right MT while the left TLE demonstrated increased DMN connectivity with the bilateral MT. There was no lateralization effect of TLE upon the DMN connectivity with ACC. These findings suggest that the resting-state functional connectivity within the DMN is reinforced in temporal lobe epilepsy during spike-free periods. Future studies are needed to examine if the altered functional connectivity can be used as a biomarker for treatment responses, cognitive dysfunction and prognosis in patients with TLE. |
| Databáze: | OpenAIRE |
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