The structure of A201A, a novel nucleoside antibiotic
| Autor: | Herbert A. Kirst, R. L. Hamill, John L. Occolowitz, Noel D. Jones, Edward Szymanski, Jonathan W. Paschal, Douglas E. Dorman |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Pharmacology
Chemical Phenomena medicine.drug_class Stereochemistry Antibiotics Molecular Conformation Nucleosides Biology Mass Spectrometry Anti-Bacterial Agents carbohydrates (lipids) Chemistry chemistry.chemical_compound Aminoglycosides chemistry Biochemistry Cinnamates Puromycin Drug Discovery medicine Hygromycin B Fermentation broth Nucleoside |
| Zdroj: | The Journal of Antibiotics. 38:575-586 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.38.575 |
| Popis: | The structure of the novel nucleoside antibiotic A201A has been determined by a combination of chemical and spectroscopic methods. It is composed of 6-dimethylaminopurine, 3-amino-3-deoxyribose, p-hydroxy-alpha-methylcinnamic acid, a novel unsaturated hexofuranose and 3,4-di-O-methylrhamnose. Structures have also been assigned to several related minor factors simultaneously isolated from the fermentation broth. These unique nucleosides have very interesting similarities and differences in structure with the known antibiotics puromycin and hygromycin A. |
| Databáze: | OpenAIRE |
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