The effect of cimetidine on maldigestion in cystic fibrosis
| Autor: | Kenneth L. Cox, Alan B. Osher, J. Nevin Isenberg, Richard R. Dooley |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cystic Fibrosis Pancreatic Extracts Guanidines Cystic fibrosis Excretion Malabsorption Syndromes Internal medicine medicine Humans Cimetidine Child Before Meals Feces Dietary fat business.industry Pancreatic exocrine insufficiency medicine.disease Celiac Disease Endocrinology Pancreatin Pediatrics Perinatology and Child Health Drug Therapy Combination Female business Pancreatic enzymes medicine.drug |
| Zdroj: | The Journal of Pediatrics. 94:488-492 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(79)80609-5 |
| Popis: | Ten patients (6 to 27 years of age) who had severe pancreatic exocrine insufficiency due to cystic fibrosis were studied to determine whether cimetidine would improve dietary fat and nitrogen absorption. When a constant diet was consumed and oral pancreatic enzymes were administered, the addition of cimetidine (150 or 200 mg taken orally one-half hour before meals) signficantly reduced fecal fat excretion from 25.3 +/- 2.9 to 17.3 +/- 2.1 gm/24 hours and fecal nitrogen excretion from 4.5 +/- 0.6 to 3.4 +/- 0.5 gm/24 hours (P less than 0.05). Lower doses of cimetidine resulted in less significant reductions of steatorrhea and azotorrhea. Cimetidine may be a useful adjunct to oral pancreatic enzyme therapy in patients with cystic fibrosis who continue to have steatorrhea and azotorrhea with enzyme therapy alone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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