FDG PET-CT evaluation in neurolymphomatosis: imaging characteristics and clinical outcomes
| Autor: | Elinor Goshen, Meirav Kedmi, Tima Davidson, Bar Chikman, Orna Komisar, Merav Lidar, Abraham Avigdor, Simona Ben-Haim, S. Tzila Zwas |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Early detection Disease 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Image Interpretation Computer-Assisted Image Processing Computer-Assisted Marek Disease Animals Humans Medicine Neoplasm Metastasis Young adult Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Fdg uptake Retrospective cohort study Hematology Patient data Middle Aged Prognosis medicine.disease Lymphoma Oncology Female Fdg pet ct Radiology business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Leukemia & Lymphoma. 59:348-356 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | Neurolymphomatosis (NL) often represents unidentified non-Hodgkin lymphoma relapses. Considering its severity, early detection and treatment are crucial. We outline one hospital's 18F-FDG-PET-CT imaging findings of NL, along with the patients' clinical characteristics. Clinical records and imaging findings of 19 NL patients, PET-CT diagnosed, were retrospectively reviewed. Patient data, FDG-PET-CT findings and the presence of coexisting diseases, especially CNS involvement, were documented. Available MRI and clinical data verified the findings. All cases had increased linear FDG uptake along anatomic nerve sites. CTs showed varying degrees of corresponding soft-tissue-thickening. Clinical correlations also contributed to the diagnosis. In 4/19 patients, lymphoma presented with NL, in 15/19 it appeared with disease recurrence/progression. In 9/19, clinical symptoms suggested neural involvement while 10/19 had nonspecific symptoms. Eleven died of lymphoma within 0.9 years of diagnosis despite directed-therapy. Eight, however, survived up to 7.82 years post-diagnosis. Whole-body FDG-PET-CT can assist in early NL diagnosis, possibly enhancing survival. |
| Databáze: | OpenAIRE |
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